Российский физиологический журнал им. И.М. Сеченова, 2023, T. 109, № 8, стр. 1056-1067
Возрастные особенности влияния холецистокинина на импульсную активность нейронов дорсомедиального и вентромедиального ядер гипоталамуса крыс
А. А. Спиричев 1, К. Ю. Моисеев 1, П. А. Анфимова 1, Г. А. Тарасова 1, П. М. Маслюков 1, *
1 Ярославский государственный медицинский университет,
Ярославль, Россия
* E-mail: mpm@ysmu.ru
Поступила в редакцию 11.05.2023
После доработки 14.06.2023
Принята к публикации 21.06.2023
- EDN: GKKVLT
- DOI: 10.31857/S0869813923080101
Полные тексты статей выпуска доступны в ознакомительном режиме только авторизованным пользователям.
Аннотация
Целью работы являлcя анализ фоновой и вызванной внутривенным введением сульфатированного октапептида холецистокинина (CCK), а также антагониста холецистокинина проглумида импульсной нейронной электрической активности в дорсомедиальном (ДМЯ) и вентромедиальном (ВМЯ) ядрах гипоталамуса у самцов молодых (2–3 мес.), взрослых (12 мес.) и старых (24 мес.) крыс под уретановым наркозом. Средняя частота фоновой импульсации нейронов при внутривенном введении CCK у молодых крыс в ДМЯ достоверно снижалась с 1.5 ± 0.4 до 0.2 ± 0.1 имп./с, в ВМЯ – с 2.0 ± 0.4 до 0.9 ± 0.2 имп./с. Одновременное введение CCK и проглумида не приводило к изменению характера нейронной активности в данной возрастной группе. У взрослых и старых крыс средняя фоновая частота разрядов нейронов ДМЯ и ВМЯ была ниже в сравнении с молодыми крысами и под влиянием CCK и проглумида достоверно не менялась. В ДМЯ и ВМЯ большая часть нейронов ингибировалась CCK, при этом в ДМЯ процент ингибируемых CCK нейронов был выше по сравнению с ВМЯ. В ДМЯ молодых животных отсутствовали нейроны, активируемые CCK, которые появлялись у взрослых и старых животных.
Полные тексты статей выпуска доступны в ознакомительном режиме только авторизованным пользователям.
Список литературы
Ambler M, Hitrec T, Wilson A, Cerri M, Pickering A (2022) Neurons in the Dorsomedial Hypothalamus Promote, Prolong, and Deepen Torpor in the Mouse. J Neurosci 42: 4267–4277. https://doi.org/10.1523/JNEUROSCI.2102-21.2022
Mieda M, Williams SC, Richardson JA, Tanaka K, Yanagisawa M (2006) The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker. Proc Natl Acad Sci U S A 103: 12150–121505. https://doi.org/10.1073/pnas.0604189103
Northeast RC, Vyazovskiy VV, Bechtold DA (2020) Eat, sleep, repeat: the role of the circadian system in balancing sleep-wake control with metabolic need. Curr Opin Physiol 15: 183–191. https://doi.org/10.1016/j.cophys.2020.02.003
Sanetra AM, Palus-Chramiec K, Chrobok L, Jeczmien-Lazur JS, Gawron E, Klich JD, Pradel K, Lewandowski MH (2022) High-Fat-Diet-Evoked Disruption of the Rat Dorsomedial Hypothalamic Clock Can Be Prevented by Restricted Nighttime Feeding. Nutrients 14: 5034. https://doi.org/10.3390/nu14235034
Sayegh AI (2013) The role of cholecystokinin receptors in the short-term control of food intake. Prog Mol Biol Transl Sci 114: 277–316. https://doi.org/10.1016/B978-0-12-386933-3.00008-X
Watts AG, Kanoski SE, Sanchez-Watts G, Langhans W (2022) The physiological control of eating: signals, neurons, and networks. Physiol Rev 102: 689–813. https://doi.org/10.1152/physrev.00028.2020
Crosby KM, Baimoukhametova DV, Bains JS, Pittman QJ (2015) Postsynaptic Depolarization Enhances GABA Drive to Dorsomedial Hypothalamic Neurons through Somatodendritic Cholecystokinin Release. J Neurosci 35: 13160–13170. https://doi.org/10.1523/JNEUROSCI.3123-14.2015
Sabatier N, Leng G (2010) Responses to cholecystokinin in the ventromedial nucleus of the rat hypothalamus in vivo. Eur J Neurosci 31: 1127–1135. https://doi.org/10.1111/j.1460-9568.2010.07144.x
Heidel E, Davidowa H (1998) Interactive effects of cholecystokinin-8S and serotonin on spontaneously active neurons in ventromedial hypothalamic slices. Neuropeptides 32(5): 423–429. https://doi.org/10.1016/s0143-4179(98)90066-x
Moiseev KY, Vishnyakova PA, Porseva VV, Masliukov AP, Spirichev AA, Emanuilov AI, Masliukov PM (2020) Changes of nNOS expression in the tuberal hypothalamic nuclei during ageing. Nitric Oxide 100–101: 1–6. https://doi.org/10.1016/j.niox.2020.04.002
Masliukov PM, Nozdrachev AD (2021) Hypothalamic Regulatory Mechanisms of Aging. J Evol Biochem Phys 57: 473–491. https://doi.org/10.1134/S0022093021030030
Moiseev KY, Spirichev AA, Vishnyakova PA, Pankrasheva LG, Masliukov PM (2021) Changes of discharge properties of neurons from dorsomedial hypothalamic nuclei during aging in rats. Neurosci Lett 762: 136168. https://doi.org/10.1016/j.neulet.2021.136168
Moiseev KY, Spirichev AA, Pankrasheva LG, Martyusheva AS, Abramova AY, Maslyukov PM (2021) Spike Activity in the Ventromedial Nucleus of Rat Hypothalamus during Aging. Bull Exp Biol Med 171: 251–253. https://doi.org/10.1007/s10517-021-05205-4
Анисимов ВН (2008) Молекулярные и физиологические механизмы старения. В 2 т. СПб. Наука. [Anisimov VN (2008) Molecular and physiological mechanisms of aging. In 2 v. SPb. Nauka. (In Russ)].
Carrascosa JM, Ros M, Andrés A, Fernández-Agulló T, Arribas C (2009) Changes in the neuroendocrine control of energy homeostasis by adiposity signals during aging. Exp Gerontol 44: 20–25. https://doi.org/10.1016/j.exger.2008.05.005
Cawthon CR, de La Serre CB (2021) The critical role of CCK in the regulation of food intake and diet-induced obesity. Peptides 138: 170492. https://doi.org/10.1016/j.peptides.2020.170492
Paxinos G, Watson C (2017) The Rat Brain in Stereotaxic Coordinates, compact 7th ed. Elsevier. Acad Press.
Kendrick K, Leng G, Higuchi T (1991) Noradrenaline, dopamine and serotonin release in the paraventricular and supraoptic nuclei of the rat in response to intravenous cholecystokinin injections. J Neuroendocrinol 3(2): 139–144. https://doi.org/10.1111/j.1365-2826.1991.tb00255.x
Watts AG, Kanoski SE, Sanchez-Watts G, Langhans W (2022) The physiological control of eating: signals, neurons, and networks. Physiol Rev 102(2): 689–813. https://doi.org/10.1152/physrev.00028.2020
Imoto D, Yamamoto I, Matsunaga H, Yonekura T, Lee ML, Kato KX, Yamasaki T, Xu S, Ishimoto T, Yamagata S, Otsuguro KI, Horiuchi M, Iijima N, Kimura K, Toda C (2021) Refeeding activates neurons in the dorsomedial hypothalamus to inhibit food intake and promote positive valence. Mol Metab 54: 101366. https://doi.org/10.1016/j.molmet.2021.101366
Dodd GT, Worth AA, Nunn N, Korpal AK, Bechtold DA, Allison MB, Myers MG Jr, Statnick MA, Luckman SM (2014) The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus. Cell Metab 20: 639–649. https://doi.org/10.1016/j.cmet.2014.07.022
Blevins JE, Morton GJ, Williams DL, Caldwell DW, Bastian LS, Wisse BE, Schwartz MW, Baskin DG (2009) Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8. Am J Physiol Regul Integr Comp Physiol 296: R476–R484. https://doi.org/10.1152/ajpregu.90544.2008
Chen J, Scott KA, Zhao Z, Moran TH, Bi S (2008) Characterization of the feeding inhibition and neural activation produced by dorsomedial hypothalamic cholecystokinin administration. Neuroscience 152(1): 178–188. https://doi.org/10.1016/j.neuroscience.2007.12.004
Noetzel S, Stengel A, Inhoff T, Goebel M, Wisser AS, Bannert N, Wiedenmann B, Klapp BF, Taché Y, Mönnikes H, Kobelt P (2009) CCK-8S activates c-Fos in a dose-dependent manner in nesfatin-1 immunoreactive neurons in the paraventricular nucleus of the hypothalamus and in the nucleus of the solitary tract of the brainstem. Regul Pept 157(1–3): 84–91. https://doi.org/10.1016/j.regpep.2009.06.009
Cai H, Haubensak W, Anthony TE, Anderson DJ (2014) Central amygdala PKC-δ(+) neurons mediate the influence of multiple anorexigenic signals. Nat Neurosci 17(9): 1240–1248. https://doi.org/10.1038/nn.3767
D’Agostino G, Lyons DJ, Cristiano C, Burke LK, Madara JC, Campbell JN, Garcia AP, Land BB, Lowell BB, Dileone RJ, Heisler LK (2016) Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit. Elife 5: e12225. https://doi.org/10.7554/elife.12225
Berthélemy P, Bouisson M, Vellas B, Moreau J, Nicole-Vaysse, Albarede JL, Ribet A (1992) Postprandial cholecystokinin secretion in elderly with protein-energy undernutrition. J Am Geriatr Soc 40: 365–369. https://doi.org/10.1111/j.1532-5415.1992.tb02136.x
Covasa M (2010) Deficits in gastrointestinal responses controlling food intake and body weight. Am J Physiol Regul Integr Comp Physiol 299: R1423–R1439. https://doi.org/10.1152/ajpregu.00126.2010
Vong L, Ye C, Yang Z, Choi B, Chua S Jr, Lowell BB (2011) Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 71: 142–154. https://doi.org/10.1016/j.neuron.2011.05.028
Yamamoto R, Ahmed N, Ito T, Gungor NZ, Pare D (2018) Optogenetic Study of Anterior BNST and Basomedial Amygdala Projections to the Ventromedial Hypothalamus. eNeuro 5: ENEURO.0204–18.2018. https://doi.org/10.1523/ENEURO.0204-18.2018
Xiao Z, Jaiswal MK, Deng PY, Matsui T, Shin HS, Porter JE, Lei S (2012) Requirement of phospholipase C and protein kinase C in cholecystokinin-mediated facilitation of NMDA channel function and anxiety-like behavior. Hippocampus 22: 1438–1450. https://doi.org/10.1002/hipo.20984
Moore SJ, Cazares VA, Temme SJ, Murphy GG (2023) Age-related deficits in neuronal physiology and cognitive function are recapitulated in young mice overexpressing the L-type calcium channel, CaV 1.3. Aging Cell 22: e13781. https://doi.org/10.1111/acel.13781
Sahu G, Turner RW (2021) The Molecular Basis for the Calcium-Dependent Slow Afterhyperpolarization in CA1 Hippocampal Pyramidal Neurons. Front Physiol 12: 759707. https://doi.org/10.3389/fphys.2021.759707
Sa M, Park MG, Lee CJ (2022) Role of Hypothalamic Reactive Astrocytes in Diet-Induced Obesity. Mol Cells 45: 65–75. https://doi.org/10.14348/molcells.2022.2044
Rust VA, Crosby KM (2021) Cholecystokinin acts in the dorsomedial hypothalamus of young male rats to suppress appetite in a nitric oxide-dependent manner. Neurosci Lett 764: 136295. https://doi.org/10.1016/j.neulet.2021.136295
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Российский физиологический журнал им. И.М. Сеченова