Успехи физиологических наук, 2023, T. 54, № 3, стр. 3-24
Иммунная функция лимфатической системы
Г. И. Лобов *
Федеральное государственное бюджетное учреждение науки Институт физиологии им. И.П. Павлова РАН, лаборатория сердечно-сосудистой и лимфатической систем
199034 Санкт-Петербург, Россия
* E-mail: LobovGI@infran.ru
Поступила в редакцию 22.03.2023
После доработки 29.03.2023
Принята к публикации 01.04.2023
- EDN: OXKSLU
- DOI: 10.31857/S0301179823030049
Полные тексты статей выпуска доступны в ознакомительном режиме только авторизованным пользователям.
Аннотация
Лимфатическая система играет определяющую роль в иммунитете, выходящую далеко за рамки простого транспорта иммунных клеток и антигенов. Эндотелиальные клетки в различных отделах этой сосудистой сети высоко специализированы для выполнения различных специфических функций. Лимфатические капилляры экспрессируют хемокины и молекулы адгезии, которые в тканях способствуют привлечению и трансмиграции иммунных клеток. Сигнальные молекулы, продуцируемые эндотелиальными клетками лимфатических капилляров при воспалении, модулируют в лимфатических узлах миграцию лимфоцитов через венулы с высоким эндотелием из крови в паренхиму лимфатических узлов. Лимфатические сосуды обеспечивают активный регулируемый транспорт иммунных клеток и антигенов в лимфатические узлы. В лимфатических узлах с их сложной структурой, организованной стромальными клетками, создаются оптимальные условия для контактов антигенпрезентирующих клеток с лимфоцитами. Различные субпопуляции лимфатических эндотелиальных клеток лимфатических узлов выполняют специфические функции в соответствии с локализацией в лимфатическом узле и способствуют как врожденному, так и приобретенному иммунному ответу посредством презентации антигена, ремоделирования лимфатического узла и регуляции входа и выхода лейкоцитов.
Полные тексты статей выпуска доступны в ознакомительном режиме только авторизованным пользователям.
Список литературы
Абдрешов С.Н., Балхыбекова А.О., Демченко Г.А., Лобов Г.И. Лимфодинамика и адренергическая иннервация почки и почечных лимфатических узлов при токсическом гепатите // Регионарное кровообращение и микроциркуляция. 2020. № 19(3). С. 73–79.https://doi.org/10.24884/1682-6655-2020-19-3-73-79
Борисов А.В. Функциональная анатомия лимфангиона // Морфология. 2005. Т. 128. № 6. С. 18–27.
Лобов Г.И. Лимфатическая система в норме и при патологии // Успехи физиологических наук. 2022. Т. 53. № 2. С. 15–38. https://doi.org/10.31857/S0301179822020060
Лобов Г.И. Электрофизиологические свойства мембраны гладкомышечных клеток лимфатических сосудов //Доклады Академии наук СССР. 1984. Т. 277. № 1. С. 244–247.
Лобов Г.И., Орлов Р.С. Саморегуляция насосной функции лимфангиона // Физиол. журн. СССР им. И.М. Сеченова. 1988. Т. 74. № 7. С. 977–988.
Лобов Г.И., Унт Д.В. Дексаметазон предотвращает сепсис-индуцированное угнетение сократительной функции лимфатических сосудов и узлов посредством ингибирования индуцибельной NO-синтазы и циклооксигеназы-2 // Рос. физиол. журн. им. И.М. Сеченова. 2019. Т. 105. № 1. С. 76–88. https://doi.org/10.1134/S0869813919010059
Сапин М.Р., Никитюк Д.Б. Лимфатическая система и ее роль в иммунных процессах. М.: Медицинская книга, 2014. 40 с.
Abadie V., Badell E., Douillard P., Ensergueix D. et al. Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes // Blood. 2005. V. 106. P. 1843–1850. https://doi.org/10.1182/blood-2005-03-1281
Acton S.E., Astarita J.L., Malhotra D. et al. Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2 // Immunity. 2012. V. 37(2). P. 276–289. https://doi.org/10.1016/j.immuni.2012.05.022
Aebischer D., Iolyeva M., Halin C. The inflammatory response of lymphatic endothelium // Angiogenesis. 2014. V. 17(2). P. 383–393. https://doi.org/10.1007/s10456-013-9404-3
Ager A. High endothelial venules and other blood vessels: critical regulators of lymphoid organ development and function // Front. Immunol. 2017. 8. 45. https://doi.org/10.3389/fimmu.2017.00045
Akl T.J., Nagai T., Cote G.L., Gashev A.A. Mesenteric lymph flow in adult and aged rats // Am J. Physiol. Heart Circ. Physiol. 2011. V. 301(5). P. H1828–H1840. https://doi.org/10.1152/ajpheart.00538.2011
Aldrich M.B., Sevick-Muraca E.M. Cytokines are systemic effectors of lymphatic function in acute inflammation // Cytokine. 2013. V. 64(1). P. 362–369. https://doi.org/10.1016/j.cyto.2013.05.015
Alrumaihi F. The Multi-Functional Roles of CCR7 in Human Immunology and as a Promising Therapeutic Target for Cancer Therapeutics // Front Mol. Biosci. 2022. V. 9. 834149. https://doi.org/10.3389/fmolb.2022.834149
Arasa J., Collado-Diaz V., Kritikos I. et al. Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation // J. Exp. Med. 2021. V. 218:e20201413. https://doi.org/10.1084/jem.20201413
Arasa J., Collado-Diaz V., Halin C. Structure and Immune Function of Afferent Lymphatics and Their Mechanistic Contribution to Dendritic Cell and T Cell Trafficking // Cells. 2021. V. 10(5). 1269. https://doi.org/10.3390/cells10051269
Arokiasamy S., Zakian C., Dilliway J. et al. Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation // Sci. Rep. 2017 V. 7:44189. https://doi.org/10.1038/srep44189
Aukland K., Reed R.K. Interstitial-lymphatic mechanisms in the control of extracellular fluid volume // Physiol. Rev. 1993. V. 73(1). P. 1–78. https://doi.org/10.1152/physrev.1993.73.1.1
Baluk P., Fuxe J., Hashizume H. et al. Functionally specialized junctions between endothelial cells of lymphatic vessels // J. Exp. Med. 2007. V. 204(10). P. 2349–2362. https://doi.org/10.1084/jem.20062596
Barral P., Polzella P., Bruckbauer A. et al. CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes // Nat. Immunol. 2010. V. 11. P. 303–312. https://doi.org/10.1038/ni.1853
Beauvillain C., Cunin P., Doni A. et al. CCR7 is involved in the migration of neutrophils to lymph nodes // Blood. 2011. V. 117. P. 1196–1204. https://doi.org/10.1182/blood-2009-11-254490
Billaud M., Lohman A.W., Johnstone S.R. et al. Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall // Pharmacol. Rev. 2014. V. 66(2). P. 513–569. https://doi.org/10.1124/pr.112.007351
Bouta E.M., Wood R.W., Brown E.B. et al. In vivo quantification of lymph viscosity and pressure in lymphatic vessels and draining lymph nodes of arthritic joints in mice // J. Physiol. 2014. V. 592. P. 1213–1223. https://doi.org/10.1113/jphysiol.2013.266700
Breslin J.W. ROCK and cAMP promote lymphatic endothelial cell barrier integrity and modulate histamine and thrombin-induced barrier dysfunction // Lymphat. Res. Biol. 2011/ V. 9. P. 3–11. https://doi.org/10.1089/lrb.2010.0016
Brinkman C.C., Iwami D., Hritzo M.K. et al. Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration // Nat. Commun. 2016. V. 7. 12021. https://doi.org/10.1038/ncomms12021
Brown M.N., Fintushel S.R., Lee M.H. et al. Chemoattractant receptors and lymphocyte egress from extralymphoid tissue: changing requirements during the course of inflammation // J. Immunol. 2010. V. 185:4873–82. https://doi.org/10.4049/jimmunol.1000676
Brulois K., Rajaraman A., Szade A. et al. A molecular map of murine lymph node blood vascular endothelium at single cell resolution // Nat. Commun. 2020. V. 11. 3798. https://doi.org/10.1038/s41467-020-17291-5
Camara A., Cordeiro O.G., Alloush F. et al. Lymph node mesenchymal and endothelial stromal cells cooperate via the RANK–RANKL cytokine axis to shape the sinusoidal macrophage niche // Immunity. 2019. V. 50. P. 1467–1481 https://doi.org/10.1016/j.immuni.2019.05.008
Card C.M., Yu S.S., Swartz M.A. Emerging roles of lymphatic endothelium in regulating adaptive immunity // J. Clin. Invest. 2014. V. 124. P. 943–952. https://doi.org/10.1172/JCI73316
Chang J.E., Turley S.J. Stromal infrastructure of the lymph node and coordination of immunity // Trends Immunol. 2015. V. 36(1). P. 30–39. https://doi.org/10.1016/j.it.2014.11.003
Chen H., Ye F., Guo G. Revolutionizing immunology with single-cell RNA sequencing // Cell Mol. Immunol. 2019. V. 16(3). P. 242–249. https://doi.org/10.1038/s41423-019-0214-4
Christiansen A.J., Dieterich L.C., Ohs I. et al. Lymphatic endothelial cells attenuate inflammation via suppression of dendritic cell maturation // Oncotarget. 2016. V. 7. P. 39421–39435. https://doi.org/10.18632/oncotarget.9820
Collin M., Bigley V. Human dendritic cell subsets: an update // Immunology. 2018. V. 154(1). P. 3–20. https://doi.org/10.1111/imm.12888
Debes G.F., Arnold C.N., Young A.J. et al. Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues // Nat. Immunol. 2005. V. 6. P. 889–894. https://doi.org/10.1038/ni1238
Detienne S., Welsby I., Collignon C. et al. Central role of CD169+ lymph node resident macrophages in the adjuvanticity of the QS-21 component of AS01 // Sci. Rep. 2016. V. 6. 39475. https://doi.org/10.1038/srep39475
Dixon J.B., Raghunathan S., Swartz M.A. A tissue-engineered model of the intestinal lacteal for evaluating lipid transport by lymphatics // Biotechnol. Bioeng. 2009. V. 103. P. 1224–1235. https://doi.org/10.1002/bit.22337
Dixon J.B., Zawieja D.C., Gashev A.A., Coté G.L. Measuring microlymphatic flow using fast video microscopy // Biomed. Opt. 2005. V. 10(6). 064016. https://doi.org/10.1117/1.2135791
Dubrot J., Duraes F.V., Potin L. et al. Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4(+) T cell tolerance // J. Exp. Med. 2014. V. 211. 1153–1166. https://doi.org/10.1084/jem.20132000
Fletcher A.L., Malhotra D., Acton SE. et al. Reproducible isolation of lymph node stromal cells reveals site-dependent differences in fibroblastic reticular cells // Front. Immunol. 2011. V. 2. 35. https://doi.org/10.3389/fimmu.2011.00035
Forster R., Davalos-Misslitz A.C., Rot A. CCR7 and its ligands: balancing immunity and tolerance // Nat. Rev. Immunol. 2008. V. 8. P. 362–71. https://doi.org/10.1038/nri2297
Fossum S. The architecture of rat lymph nodes. IV. Distribution of ferritin and colloidal carbon in the draining lymph nodes after foot-pad injection // Scand. J. Immunol. 1980. V. 12. P. 433–441. https://doi.org/10.1111/j.1365-3083.1980.tb00087.x
Garnier L., Gkountidi A.O., Hugues S. Tumor-Associated Lymphatic Vessel Features and Immunomodulatory Functions // Front. Immunol. 2019. V. 10. 720. https://doi.org/10.3389/fimmu.2019.00720
Garrafa E., Imberti L., Tiberio G. et al. Heterogeneous expression of toll-like receptors in lymphatic endothelial cells derived from different tissues // Immunol. Cell Biol. 2011. V. 89. P. 475–481. https://doi.org/10.1038/icb.2010.111
Gascoigne N.R.J., Rybakin V., Acuto O., Brzostek J. TCR signal strength and T cell development // Annu. Rev. Cell Dev. Biol. 2016. V. 32. P. 327–348. https://doi.org/10.1146/annurev-cellbio-111315-125324
Gerner M.Y., Torabi-Parizi P., Germain R.N. Strategically localized dendritic cells promote rapid T cell responses to lymph-borne particulate antigens // Immunity. 2015. V. 42. P. 172–185. https://doi.org/10.1016/j.immuni.2014.12.024
Ghani S., Feuerer M., Doebis C. et al. T cells as pioneers: antigen-specific T cells condition inflamed sites for high-rate antigen-non-specific effector cell recruitment // Immunology. 2009. V. 128. e870–e880. https://doi.org/10.1111/j.1365-2567.2009.03096.x
Ginhoux F., Jung S. Monocytes and macrophages: developmental pathways and tissue homeostasis // Nat. Rev. Immunol. 2014. V. 14. P. 392–404. https://doi.org/10.1038/nri3671
Gómez D., Diehl M.C., Crosby E.J. et al. Effector T cell egress via afferent lymph modulates local tissue inflammation // J. Immunol. 2015. V. 195. P. 3531–3536. https://doi.org/10.4049/jimmunol.1500626
Grasso C., Pierie C., Mebius R.E., van Baarsen L.G.M. Lymph node stromal cells: subsets and functions in health and disease // Trends Immunol. 2021. V. 42(10). P. 920–936. https://doi.org/10.1016/j.it.2021.08.009
Gray E.E., Jason G., Cyster J.G. Lymph Node Macrophages // J. Innate. Immun. 2012. V. 4(5–6). P. 424–436. https://doi.org/10.1159/000337007
Guyton A.C., Taylor A.E., Brace R.A. A synthesis of interstitial fluid regulation and lymph formation // Fed. Proc. 1976. V. 35(8). P. 1881–1885.
Hampton H.R., Chtanova T. Lymphatic Migration of Immune Cells // Front. Immunol. 2019. V. 10. 1168. https://doi.org/10.3389/fimmu.2019.01168
Hashimoto D., Miller J., Merad M. Dendritic cell and macrophage heterogeneity in vivo // Immunity. 2011. V. 35. P. 323–335. https://doi.org/10.1016/j.immuni.2011.09.007
Heesters B.A., van der Poel C.E., Das A., Carroll M.C. Antigen presentation to B cells // Trends Immunol. 2016. V. 37. P. 844–854. https://doi.org/10.1016/j.it.2016.10.003
Hirosue S., Vokali E., Raghavan V.R. et al. Steady-state antigen snging, cross-presentation, and CD8+ T cell priming: a new role for lymphatic endothelial cells // J. Immunol. 2014. V. 192. P. 5002–5011. https://doi.org/10.4049/jimmunol.1302492
Hunter M.C., Teijeira A., Montecchi R. et al. Dendritic Cells and T Cells Interact Within Murine Afferent Lymphatic Capillaries // Front. Immunol. 2019. V. 10. 520. https://doi.org/10.3389/fimmu.2019.00520
Jackson D.G. Leucocyte Trafficking via the Lymphatic Vasculature- Mechanisms and Consequences // Front. Immunol. 2019. V. 10. 471. https://doi.org/10.3389/fimmu.2019.00471
Jakubzick C., Gautier E.L., Gibbings S.L. et al. Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes // Immunity. 2013. V. 39. P. 599–610. https://doi.org/10.1016/j.immuni.2013.08.007
Jalkanen S., Salmi M. Lymphatic endothelial cells of the lymph node // Nat. Rev. Immunol. 2020. V. 20(9). 566–578. https://doi.org/10.1038/s41577-020-0281-x
Johnson L.A. In Sickness and in Health: The Immunological Roles of the Lymphatic System // Int. J. Mol. Sci. 2021. V. 22(9). P. 4458. https://doi.org/10.3390/ijms2209445
Johnson L.A, Jackson D.G. Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration // Int. Immunol. 2010. V. 22(10). P. 839–49. https://doi.org/10.1093/intimm/dxq435
Johnson L.A., Clasper S., Holt A.P. et al. An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium // J. Exp. Med. 2006. V. 203(12). P. 2763–2777. https://doi.org/10.1084/jem.20051759
Johnson L.A., Banerji S., Lagerholm B.C., Jackson D.G. Dendritic cell entry to lymphatic capillaries is orchestrated by CD44 and the hyaluronan glycocalyx // Life Sci. Alliance. 2021. V. 4(5). e202000908. https://doi.org/10.26508/lsa.202000908
Junt T., Moseman E.A., Iannacone M. et al. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells // Nature. 2007. V. 450. P. 110–114. https://doi.org/10.1038/nature06287
Kabashima K., Shiraishi N., Sugita K. et al. CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells // Am. J. Pathol. 2007. V. 171. P. 1249–1257. https://doi.org/10.2353/ajpath.2007.070225
Kähäri L., Fair-Mäkelä R., Auvinen K. et al. Transcytosis route mediates rapid delivery of intact antibodies to draining lymph nodes // J. Clin. Invest. 2019. V. 129. P. 3086–3102. https://doi.org/10.1172/JCI125740
Kastenmüller W., Torabi-Parizi P., Subramanian N. et al. A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread // Cell. 2012. V. 150. P. 1235–1248. https://doi.org/10.1016/j.cell.2012.07.021
Kim H., Kataru R.P., Koh G.Y. Regulation and implications of inflammatory lymphangiogenesis // Trends Immunol. 2012. V. 33(7). P. 350–356. https://doi.org/10.1016/j.it.2012.03.006
Lammermann T., Bader B.L., Monkley S.J. et al. Rapid leukocyte migration by integrin-independent flowing and squeezing // Nature. 2008. V. 453. P. 51–55. https://doi.org/10.1038/nature06887
Lee K.M., McKimmie C.S., Gilchrist D.S. et al. D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion // Blood. 2011. V. 118. P. 6220–6229. https://doi.org/10.1182/blood-2011-03-344044
Leirião P., del Fresno C., Ardavín C. Monocytes as effector cells: activated Ly-6C(high) mouse monocytes migrate to the lymph nodes through the lymph and cross-present antigens to CD8+ T cells // Eur. J. Immunol. 2012. V. 42. P. 2042–2051. https://doi.org/10.1002/eji.201142166
Levick J.R., Michel C.C. Microvascular fluid exchange and the revised Starling principle // Cardiovasc. Res. 2010. V. 87. P. 198–210. https://doi.org/10.1093/cvr/cvq062
Link A., Vogt T.K., Favre S. et al. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells // Nat. Immunol. 2007. V. 8. P. 1255–1265. https://doi.org/10.1038/ni1513
Lobov G.I. Location and properties of the pacemaker cells of the lymphangion // Doklady Biological Sciences. 1987. V. 294(2). P. 503–506.
Louie D.A.P., Liao S. Lymph Node Subcapsular Sinus Macrophages as the Frontline of Lymphatic Immune Defense // Front. Immunol. 2019. V. 28(10). 347. https://doi.org/10.3389/fimmu.2019.00347
Low S., Hirakawa J., Hoshino H. et al. Role of MAdCAM-1-expressing high endothelial venule-like vessels in colitis induced in mice lacking sulfotransferases catalyzing l-selectin ligand biosynthesis // J. Histochem. Cytochem. 2018. V. 66. P. 415–425. https://doi.org/10.1369/0022155417753363
Lukacs-Kornek V., Malhotra D., Fletcher A.L. et al. Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes // Nat. Immunol. 2011. V. 12. P. 1096–1104. https://doi.org/10.1038/ni.2112
Ma Q., Dieterich L.C., Detmar M. Multiple roles of lymphatic vessels in tumor progression // Curr. Opin. Immunol. 2018. V. 53. P. 7–12. https://doi.org/10.1016/j.coi.2018.03.018
Maddaluno L., Verbrugge S.E., Martinoli C. et al. The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cells // J. Exp. Med. 2009. V. 206. P. 623–635. https://doi.org/10.1084/jem.20081211
Malhotra D., Fletcher A.L., Turley S.J. Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity // Immunol. Rev. 2013. V. 251. P. 160–176. https://doi.org/10.1111/imr.12023
Martens J.H., Kzhyshkowska J., Falkowski-Hansen M. et al. Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis // J. Pathol. 2006. V. 208. P. 574–589. https://doi.org/10.1002/path.1921
Mazzone M., Bergers G. Regulation of blood and lymphatic vessels by immune cells in tumors and metastasis // Ann. Rev. Physiol. 2019. V. 81. P. 535–560. https://doi.org/10.1146/annurev-physiol-020518-114721
Michel C.C., Nanjee M.N., Olszewski W.L., Miller N.E. LDL and HDL transfer rates across peripheral microvascular endothelium agree with those predicted for passive ultrafiltration in humans // J. Lipid Res. 2015. V. 56. P. 122–128. https://doi.org/10.1194/jlr.M055053
Miteva D.O., Rutkowski J.M., Dixon J.B. et al. Transmural flow modulates cell and fluid transport functions of lymphatic endothelium // Circ. Res. 2010. V. 106. P. 920–931. https://doi.org/10.1161/CIRCRESAHA.109.207274
Mehta D., Malik A.B. Signaling mechanisms regulating endothelial permeability // Physiol. Rev. 2006. V. 86(1). P. 279–367. https://doi.org/10.1152/physrev.00012.2005
Moseman E.A., Iannacone M., Bosurgi L. et al. B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity // Immunity. 2012. V. 36. P. 415–426. https://doi.org/10.1016/j.immuni.2012.01.013
Nitschké M., Aebischer D., Abadier M. et al. Differential requirement for ROCK in dendritic cell migration within lymphatic capillaries in steady-state and inflammation // Blood. 2012. V. 120(11). P. 2249–2258. https://doi.org/10.1182/blood-2012-03-417923
Ohtani O., Ohtani Y. Structure and function of rat lymph nodes // Arch. Histol. Cytol. 2008. V. 71(2). P. 69–76. https://doi.org/10.1679/aohc.71.6
Palframan R.T., Jung S., Cheng G. et al. Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues // J. Exp. Med. 2001. V. 194 P. 1361–1373. https://doi.org/10.1084/jem.194.9.1361
Permanyer M., Bošnjak B., Förster R. Dendritic cells, T cells and lymphatics: dialogues in migration and beyond // Curr. Opin. Immunol. 2018. V. 53. P. 173–179. https://doi.org/10.1016/j.coi.2018.05.004
Pflicke H., Sixt M. Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels // J. Exp. Med. 2009. V. 206. P. 2925–2935. https://doi.org/10.1084/jem.20091739
Poirot J., Medvedovic J., Trichot C., Soumelis V. Compartmentalized multicellular crosstalk in lymph nodes coordinates the generation of potent cellular and humoral immune responses // Eur. J. Immunol. 2021. V. 51(12). P. 3146–3160. https://doi.org/10.1002/eji.202048977
Quast T., Zölzer K., Guu D. et al. A Stable Chemokine Gradient Controls Directional Persistence of Migrating Dendritic Cells // Front. Cell Dev. Biol. 2022. V. 10. 943041. https://doi.org/10.3389/fcell.2022.943041
Randolph G.J., Bala S., Rahier J.F. et al. Lymphoid aggregates remodel lymphatic collecting vessels that serve mesenteric lymph nodes in Crohn disease // Am. J. Pathol. 2016. V. 186(12). P. 3066–3073. https://doi.org/10.1016/j.ajpath.2016.07.026
Reed R.K., Rubin K. Transcapillary exchange: role and importance of the interstitial fluid pressure and the extracellular matrix // Cardiovasc. Res. 2010. V. 87(2). P. 211–217. https://doi.org/10.1093/cvr/cvq143
Roozendaal R., Mempel T.R., Pitcher L.A. et al. Conduits mediate transport of low-molecular-weight antigen to lymph node follicles // Immunity. 2009. V. 30. P. 264–276. https://doi.org/10.1016/j.immuni.2008.12.014
Rouhani S.J., Eccles J.D., Riccardi P. et al. Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction // Nat. Commun. 2015. V. 6. 6771. https://doi.org/10.1038/ncomms7771
Russo E., Nitschké M., Halin C. Dendritic cell interactions with lymphatic endothelium // Lymphat. Res. Biol. 2013. V. 11(3). P. 172–82. https://doi.org/10.1089/lrb.2013.0008
Russo E., Teijeira A., Vaahtomeri K. et al. Intralymphatic CCL21 promotes tissue egress of dendritic cells through afferent lymphatic vessels // Cell Rep. 2016. V. 14. P. 1723–1734. https://doi.org/10.1016/j.celrep.2016.01.048
Sagris M., Theofilis P., Antonopoulos A.S. et al. Inflammation in Coronary Microvascular Dysfunction // Int. J. Mol. Sci. 2021. V. 22(24). 13471. https://doi.org/10.3390/ijms222413471
Santambrogio L. The Lymphatic Fluid // Int. Rev. Cell Mol. Biol. 2018. V. 337. P. 111–133. https://doi.org/10.1016/bs.ircmb.2017.12.002
Santambrogio L., Berendam S.J., Engelhard V.H. The Antigen Processing and Presentation Machinery in Lymphatic Endothelial Cells // Front. Immunol. 2019. V. 10. 1033. https://doi.org/10.3389/fimmu.2019.01033
Saxena V., Li L., Paluskievicz C., Kasinath V. et al. Role of lymph node stroma and microenvironment in T cell tolerance // Immunol. Rev. 2019. V. 292(1). P. 9–23. https://doi.org/10.1111/imr.12799
Schineis P., Runge P., Halin C. Cellular traffic through afferent lymphatic vessels // Vascul. Pharmacol. 2019. V. 112. P. 31–41. https://doi.org/10.1016/j.vph.2018.08.001
Schmid-Schönbein G.W. Microlymphatics and lymph flow // Physiol. Rev. 1990. V. 70(4). P. 987–1028. https://doi.org/10.1152/physrev.1990.70.4.987
Schwab S.R., Cyster J.G. Finding a way out: lymphocyte egress from lymphoid organs // Nat. Immunol. 2007. V. 8(12). P. 1295–1301. https://doi.org/10.1038/ni1545
Schwager S., Detmar M. Inflammation and Lymphatic Function //Front. Immunol. 2019. V. 10. 308. https://doi.org/10.3389/fimmu.2019.00308
Shields J.D., Fleury M.E., Yong C. et al. Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling // Cancer Cell. 2007. V. 11. P. 526–538. https://doi.org/10.1016/j.ccr.2007.04.020
Stewart R.H. A Modern View of the Interstitial Space in Health and Disease // Front. Vet. Sci. 2020. V. 7. 609 583. https://doi.org/10.3389/fvets.2020.609583
Sura R., Colombel J.F., Van Kruiningen H.J. Lymphatics, tertiary lymphoid organs and the granulomas of Crohn’s disease: an immunohistochemical study // Aliment. Pharmacol. Ther. 2011. V. 33(8). P. 930–939. https://doi.org/10.1111/j.1365-2036.2011.04605.x
Swartz M.A., Fleury M.E. Interstitial Flow and Its Effects in Soft Tissues // Annu. Rev. Biomed. Eng. 2007. V. 9. P. 229–256. https://doi.org/10.1146/annurev.bioeng.9.060906.151850
Ta O., Lim H.Y., Gurevich I. et al. DC mobilization from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling // J. Exp.Med. 2011. V. 208. P. 2141–2153. https://doi.org/10.1084/jem.20102392
Talsma D.T., Katta K., Boersema M. et al. Increased migration of antigen presenting cells to newly-formed lymphatic vessels in transplanted kidneys by glycol-split heparin // PLoS One. 2017. V. 12(6). e0180206. https://doi.org/10.1371/journal.pone.0180206
Tamburini B.A., Burchill M.A., Kedl R.M. Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection // Nat. Commun. 2014. V. 5. 3989. https://doi.org/10.1038/ncomms4989
Tecchio C., Micheletti A., Cassatella M.A. Neutrophil-derived cytokines: facts beyond expression // Front. Immunol. 2014. V. 5. 508. https://doi.org/10.3389/fimmu.2014.00508
Teijeira A., Palazon A., Garasa S. et al. CD137 on inflamed lymphatic endothelial cells enhances CCL21-guided migration of dendritic cells // FASEB J. 2012. V. 26. P. 3380–3392. https://doi.org/10.1096/fj.11-201061
Teijeira A., Hunter M.C., Russo E. et al. T cell migration from inflamed skin to draining lymph nodes requires intralymphatic crawling supported by ICAM-1/LFA-1 interactions // Cell Rep. 2017. V. 18. P. 857–865. https://doi.org/10.1016/j.celrep.2016.12.078
Theocharis A.D., Manou D., Karamanos N.K. The extracellular matrix as a multitasking player in disease // FEBS J. 2019. V. 286(15). P. 2830–2869. https://doi.org/10.1111/febs.14818
Thomson C.A., van de Pavert S.A., Stakenborg M. et al. Expression of the atypical chemokine receptor ACKR4 identifies a novel population of intestinal submucosal fibroblasts that preferentially expresses endothelial cell regulators // J. Immunol. 2018. V. 201. P. 215–229. https://doi.org/10.4049/jimmunol.1700967
Tomura M., Honda T., Tanizaki H. et al. Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice // J. Clin. Invest. 2010. V. 120. P. 883–93. https://doi.org/10.1172/JCI40926
Triacca V., Guc E., Kilarski W.W., Pisano M., Swartz M.A. Transcellular pathways in lymphatic endothelial cells regulate changes in solute transport by fluid stress // Circ. Res. 2017. V. 120. P. 1440–1452. https://doi.org/10.1161/CIRCRESAHA.116.309828
Ueno H., Klechevsky E., Morita R. et al. Dendritic cell subsets in health and disease // Immunol Rev. 2007. V. 219. P. 118–142. https://doi.org/10.1111/j.1600-065X.2007.00551.x
Ulvmar M.H., Mäkinen T. Heterogeneity in the lymphatic vascular system and its origin // Cardiovasc. Res. 2016. V. 111(4). P. 310–321. https://doi.org/10.1093/cvr/cvw175
Vigl B., Aebischer D., Nitschke M., Iolyeva M. et al. Tissue inflammation modulates gene expression of lymphatic endothelial cells and dendritic cell migration in a stimulus-dependent manner // Blood. 2011. V. 118. P. 205–215. https://doi.org/10.1182/blood-2010-12-326447
Weber M., Hauschild R., Schwarz J. et al. Interstitial dendritic cell guidance by haptotactic chemokine gradients // Science. 2013. V. 339(6117). P. 328–332. https://doi.org/10.1126/science.1228456
Wiig H., Swartz M.A. Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer // Physiol. Rev. 2012. V. 92(3). P. 1005–1060. https://doi.org/10.1152/physrev.00037.201
Xiang M., Grosso R.A, Takeda A. et al. A single-cell transcriptional roadmap of the mouse and human lymph node lymphatic vasculature // Front. Cardiovasc. Med. 2020. V. 7. 52. https://doi.org/10.3389/fcvm.2020.00052
Xu H., Guan H., Zu G., Bullard D. et al. The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node // Eur. J. Immunol. 2001. V. 31. P. 3085–3093. https://doi.org/10.1002/1521-4141(2001010)31:10<3085::aid-immu3085>3.0.co;2-b
Yan Y., Zhang G.X., Gran B., Fallarino F. et al. IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis // J. Immunol. 2010. V. 185(10). P. 5953–5961. https://doi.org/10.4049/jimmunol.1001628
Yanagawa Y., Onoe K. CCR7 ligands induce rapid endocytosis in mature dendritic cells with concomitant up-regulation of Cdc42 and Rac activities // Blood. 2003. V. 101. P. 4923–4929. https://doi.org/10.1182/blood-2002-11-3474
Yawalkar N., Hunger R.E., Pichler W.J. et al. Human afferent lymph from normal skin contains an increased number of mainly memory / effector CD4(+) T cells expressing activation, adhesion and co-stimulatory molecules // Eur. J. Immunol. 2000. V. 30. P. 491–497. https://doi.org/10.1002/1521-4141(200002)30:2<491::AID-IMMU491>3.0.CO;2-H
Zawieja D.C., Thangaswamy S., Wang W. et al. Lymphatic Cannulation for Lymph Sampling and Molecular Delivery // J. Immunol. 2019. V. 203(8). P. 2339–2350. https://doi.org/10.4049/jimmunol.1900375
Zhu J., Yamane H., Paul W.E. Differentiation of effector CD4 T cell populations // Annu. Rev. Immunol. 2010. V. 28. P. 445–489. https://doi.org/10.1146/annurev-immunol-030409-101212
Дополнительные материалы отсутствуют.
Инструменты
Успехи физиологических наук