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Успехи физиологических наук, 2023, T. 54, № 4, стр. 57-72

Взаимодействие кортикотропин-рилизинг фактора и капсаицин-чувствительных афферентных нейронов в гастропротекции

Н. И. Ярушкина a, *, Т. Т. Подвигина a, **, О. Ю. Морозова a, ***, Л. П. Филаретова a, ****

a Федеральное государственное бюджетное учреждение науки Институт физиологии им. И.П. Павлова РАН, лаборатория экспериментальной эндокринологии
199034 Санкт, Петербург, Россия

* E-mail: yarushkinani@infran.ru
** E-mail: podviginatt@infran.ru
*** E-mail: morozovaoyu@infran.ru
**** E-mail: filaretovalp@infran.ru

Поступила в редакцию 01.06.2023
После доработки 12.06.2023
Принята к публикации 20.06.2023

Аннотация

Кортикотропин-рилизинг фактор (КРФ) и капсаицин-чувствительные афферентные нейроны с эфферентно-подобной функцией (КЧН) вносят важный вклад в регуляцию функций желудочно-кишечного тракта (ЖКТ) и гастропротекцию. Цель обзора заключалась в анализе данных литературы, в том числе и результатов собственных исследований, о взаимодействии КРФ и КЧН в обеспечении гастропротекции и регуляции функций ЖКТ, с фокусом на наиболее изученное их взаимодействие в регуляции моторной функции ЖКТ. На основании результатов исследований авторов обзора обсуждается возможность вклада КЧН в реализацию гастропротективного влияния КРФ и, наоборот, возможность участия КРФ в обеспечении гастропротективного действия капсацина, активирующего КЧН. Рассматривается вклад глюкокортикоидных гормонов в реализацию гастропротективного действия КРФ и компенсаторная гастропротективная роль данных гормонов в условиях выключения из функционирования КЧН.

Ключевые слова: желудочно-кишечный тракт, кортикотропин-рилизинг фактор, капсаицин-чувствительные афферентные нейроны, глюкокортикоидные гормоны, гастропротекция, моторика желудочно-кишечного тракта

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