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  4. T. 510, № 1, 2023

Доклады Российской академии наук. Науки о жизни, 2023, T. 510, № 1, стр. 236-242

ИНТЕРАКТОМ ПАРАОКСОНАЗЫ PON2 УКАЗЫВАЕТ НА НОВЫЕ ПУТИ РЕГУЛЯЦИИ РОСТА ОПУХОЛЕЙ

В. Д. Карлов 1, 2, Н. Б. Пестов 1, 3, 4, 5, М. И. Шахпаронов 1, Т. В. Корнеенко 1, *

1 Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук
Москва, Россия

2 Всероссийский научно-исследовательский институт сельскохозяйственной биотехнологии
Москва, Россия

3 Московский физико-технический институт
Долгопрудный, Московская обл., Россия

4 Федеральный научный центр исследований и разработки иммунобиологических препаратов им. М.П. Чумакова Российской академии наук
Москва, Россия

5 Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича
Москва, Россия

* E-mail: tvkorn@gmail.com

Поступила в редакцию 30.11.2022
После доработки 15.12.2022
Принята к публикации 15.12.2022

Аннотация

Исследован интерактом белка параоксоназы-2, кодируемой геном PON2. Проведен скрининг библиотеки кДНК при помощи дрожжевой двугибридной системы с целью поиска новых белков, взаимодействующих с PON2 человека. Анализ идентифицированных кандидатов наряду с ранее опубликованными данными по интеракторам, полученными другими методами, указывает на наличие значительного количества непрямых взаимосвязей PON2 с EGFR и, соответственно, возможные регуляции роста опухолей с мутациями EGFR при участии PON2.

Ключевые слова: интерактом, параоксоназа, двугибридный дрожжевой скрининг, PON2, PPP4R2, ACAA2, DCN, CFAP53/CCDC11, SFRP4, ITM2A

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