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  4. T. 73, № 5, 2023

Журнал высшей нервной деятельности им. И.П. Павлова, 2023, T. 73, № 5, стр. 579-605

Координирующая роль актинового цитоскелета в кратковременной нейросетевой пластичности с участием возбуждающих и тормозных синапсов

И. В. Кудряшова *

Федеральное государственное бюджетное учреждение науки Институт высшей нервной деятельности и нейрофизиологии РАН
Москва, Россия

* E-mail: iv_kudryashova@mail.ru

Поступила в редакцию 19.04.2023
После доработки 20.06.2023
Принята к публикации 03.07.2023

Аннотация

Проблема частотного кодирования тесно связана с исследованиями механизмов участия тормозных интернейронов в нейросетевой пластичности. В работе изложены основные принципы интеграции тормозных интернейронов в формирование пространственно-временного паттерна активности нейронов при обработке сигнала. Анализируются современные представления о динамическом характере синаптических реакций и их нестабильности в ходе текущей активности. Представленные результаты свидетельствуют о том, что кратковременная пластичность осуществляется в тесном взаимодействии возбуждающих и тормозных синапсов. Обсуждается влияние тормозных потенциалов на активность внутриклеточных посредников, влияющих на динамику постсинаптических модификаций возбуждающих и тормозных синапсов. К настоящему времени многое известно о молекулярных механизмах таких модификаций, однако никаких концептуальных представлений о ключевых факторах, объединяющих реакции внутриклеточного сигналинга в единую систему, обеспечивающую сбалансированность и “адаптивность” модификаций возбуждающих и тормозных синапсов, до сих пор не предлагалось. Приводятся аргументы в пользу координирующей роли актинового цитоскелета. Предполагается, что источником постсинаптических модификаций тормозных синапсов является быстрая адаптация актинового цитоскелета и ассоциированных с ним белков к любым отклонениям от оптимального баланса между возбуждением и торможением.

Ключевые слова: кратковременная пластичность, тормозный контроль, актиновый цитоскелет, дестабилизация синапсов, латеральная диффузия ГАМКА-рецепторов

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