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  4. T. 57, № 4, 2023

Молекулярная биология, 2023, T. 57, № 4, стр. 692-705

Математическое моделирование процесса репликации ВИЧ и ответа системы интерферона

И. А. Гайнова a, *, А. Е. Соболева b, Д. С. Гребенников c, d, Г. А. Бочаров c, d

a Институт математики им. С.Л. Соболева Сибирского отделения Российской академии наук
630090 Новосибирск, Россия

b Московский физико-технический институт (Национальный исследовательский университет)
141701 Московская область, Долгопрудный, Россия

c Институт вычислительной математики им. Г.И. Марчука Российской академии наук
119333 Москва, Россия

d Первый Московский государственный медицинский университет им. И.М. Сеченова Министерства здравоохранения России
119991 Москва, Россия

* E-mail: gajnova@math.nsc.ru

Поступила в редакцию 09.08.2022
После доработки 29.11.2022
Принята к публикации 24.12.2022

Аннотация

Разработка физиологически содержательных математических моделей, описывающих многоуровневую регуляцию в сложной сети иммунных ответов, в частности системы интерферонрегулируемых процессов репликации вирусов, является фундаментальной научной задачей в рамках межинтеграционного системного подхода к исследованиям в иммунологии. В работе представлена детальная математическая модель высокого разрешения, описывающая репликацию вируса иммунодефицита человека (ВИЧ), ответ системы интерферона (ИФН) I типа на проникновение вируса в клетку и подавление действия ИФН-индуцируемых белков вспомогательными белками ВИЧ. В результате проведенного исследования впервые разработана модель, учитывающая взаимодействие всех трех процессов. Математическая модель представляет собой систему из 37 нелинейных обыкновенных дифференциальных уравнений, включающую 78 параметров. Особенность модели заключается в том, что в ней описаны не только процессы, вовлеченные в интерфероновый ответ клетки на заражение вирусом, но также используемые вирусом механизмы, препятствующие действию системы ИФН.

Ключевые слова: математическая модель, вирус иммунодефицита человека, репликация, вспомогательные белки, интерферон типа 1, интерфероновый ответ, индуцируемые интерфероном белки

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