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  4. T. 40, № 3, 2023

Биологические мембраны: Журнал мембранной и клеточной биологии, 2023, T. 40, № 3, стр. 155-171

BAR-домен-содержащие белки как возможные регуляторы белковой жидкой фазы в нервных окончаниях в центральной нервной системе

А. Г. Шишков a, Н. В. Нифантова a, О. М. Коренькова a, Е. С. Сопова a, b, Л. Бродин b, О. В. Шупляков a, b, *

a Санкт-Петербургский государственный университет, Институт трансляционной биомедицины, лаборатория биологии синапсов
199034 Санкт-Петербург, Россия

b Отдел нейронаук, Каролинский институт
17177 Стокгольм, Швеция

* E-mail: oleg.shupliakov@ki.se

Поступила в редакцию 10.11.2022
После доработки 18.12.2022
Принята к публикации 20.12.2022

Аннотация

BAR-белки являются одними из ключевых компонентов секреторного везикулярного цикла в нервных окончаниях. Они участвуют в регуляции секреции нейромедиаторов при слиянии синаптических везикул с пресинаптической мембраной, а также в рециркуляции везикул в результате эндоцитоза. Локализация этих белков в зонах нервных окончаний, где формируются жидкие белковые фазы, предполагает дополнительные функции этих молекул. В данном обзоре мы обсуждаем функции BAR-домен-содержащих белков на различных этапах секреторного цикла, включая их возможную роль в регуляции формирования белковых жидких фаз в нервных окончаниях при синаптической активности. Мы предполагаем, что BAR-белки, помимо регуляции экзо- и эндоцитоза, играют важную роль в организации резервного пула везикул и на промежуточных этапах секреторного цикла.

Ключевые слова: синапс, цикл синаптических везикул, экзоцитоз, эндоцитоз, BAR-белки, разделение жидких фаз

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