Цитология, 2023, T. 65, № 5, стр. 407-419
Функциональные взаимодействия BAF и LEM-белков в процессах формирования половых клеток
И. О. Боголюбова 1, Д. С. Боголюбов 1, *
1 Институт цитологии РАН
194064 Санкт-Петербург, Россия
* E-mail: dbogol@mail.ru
Поступила в редакцию 27.04.2023
После доработки 27.05.2023
Принята к публикации 12.06.2023
- EDN: PISDQF
- DOI: 10.31857/S0041377123050036
Полные тексты статей выпуска доступны в ознакомительном режиме только авторизованным пользователям.
Аннотация
Восстановление структуры ядра после деления клетки требует особых взаимодействий между интегральными белками внутренней ядерной мембраны, имеющими особый LEM-домен (LEMD), белками ядерной ламины (ламинами) и консервативным белком BAF, который выступает в качестве центрального звена в этих взаимодействиях, обеспечивающих топологические взаимоотношения хроматина и ядерной оболочки. Динамические преобразования этих белковых ансамблей в митотическом цикле детально охарактеризованы на молекулярном уровне, однако меньшее внимание уделяется формирующимся половым клеткам, претерпевающим мейотические деления, несмотря на то, что их ядра (особенно в случае диплотенных ооцитов) по своей структуре существенно отличаются от соматических клеток. В настоящем обзоре обобщены пока еще относительно немногочисленные экспериментальные данные, доказывающие значимость функциональных взаимодействий BAF и LEMD-белков для формирования гамет, начиная с выделения клеток зародышевой линии и заканчивая превращением гаплоидных сперматид в морфологически зрелые сперматозоиды.
Полные тексты статей выпуска доступны в ознакомительном режиме только авторизованным пользователям.
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