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Коллоидный журнал, 2023, T. 85, № 5, стр. 566-582

Стимул-чувствительные системы для доставки лекарств на основе бислойных липидных везикул: новые тенденции

А. А. Ефимова 1, *, А. В. Сыбачин 1

1 Московский государственный университет имени М.В. Ломоносова, химический факультет
119991 Москва, Ленинские горы, 1, стр. 3, Россия

* E-mail: ephimova@genebee.msu.su

Поступила в редакцию 07.07.2023
После доработки 27.07.2023
Принята к публикации 31.07.2023

Аннотация

Разработка новых эффективных способов борьбы с тяжелыми заболеваниями, среди которых особое место занимают онкологические и инфекционные, остается актуальной задачей биомедицины и биотехнологии. В настоящее время усилия ученых сосредоточены на поисках лекарственных систем, обеспечивающих высокую эффективность лечения при минимальном воздействии на организм. Развитие этого направления привело к созданию стимул-чувствительных липосом, которые могут высвобождать инкапсулированное лекарство в ответ на определенный стимул: температуру, pH, электромагнитное поле, свет и др. Под воздействием стимула липидные бислойные везикулы изменяют структуру, размер, поверхностный заряд или фазовое состояние, что приводит к контролируемому высвобождению лекарственного препарата в определенном месте в организме, что позволяет добиться более точной и эффективной доставки. В данном обзоре обсуждаются современные тенденции в разработке стимул-чувствительных систем на основе липосом для контролируемой доставки биологически активных веществ.

Ключевые слова: липосома, стимул-чувствительные, доставка лекарств, биомедицина, биотехнология, инкапсулированное вещество, тераностика

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