Молекулярная биология, 2023, T. 57, № 6, стр. 1043-1057

Редокс-каталитические свойства кобаламинов

Ю. В. Шаталин a*, В. С. Шубина a, М. Е. Соловьева a, В. С. Акатов a

a Институт теоретической и экспериментальной биофизики Российской академии наук
142290 Пущино, Московская обл., Россия

* E-mail: yury.shatalin@yandex.ru

Поступила в редакцию 03.05.2023
После доработки 17.05.2023
Принята к публикации 18.05.2023

Аннотация

Витамин B12, или кобаламин, жизненно необходимый для функционирования организма, используется в терапии дефицитных состояний. Витамин B12 обладает противовоспалительными и антиоксидантными свойствами, что может играть важную роль в предотвращении ряда заболеваний. При этом в комбинации с такими восстановителями, как аскорбат (витамин С) и тиолы, витамин В12 проявляет прооксидантную активность. В представленном обзоре рассмотрена роль витамина B12 в патогенезе заболеваний, сопровождающихся воспалением и окислительным стрессом, а также влияние этого витамина в отдельности и в сочетании с различными восстановителями, такими как аскорбат и тиолы, на развитие окислительного стресса. Обсуждаются механизмы прооксидантного действия сочетаний разных форм кобаламина (цианокобаламин, гидроксокобаламин) с восстановителями, понимание которых необходимо для разработки стратегий применения В12 в медицине.

Ключевые слова: гидроксокобаламин, цианокобаламин, окисление тиолов, активные формы кислорода, цитотоксичность

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