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Российский физиологический журнал им. И.М. Сеченова, 2023, T. 109, № 5, стр. 588-599

Влияние травмы спинного мозга на Р2-сигнализацию в холинергическом синапсе

А. Е. Хайруллин 1, 2, *, Д. В. Ефимова 1, А. А. Еремеев 2, Д. Э. Сабирова 2, С. Н. Гришин 1, А. У. Зиганшин 1

1 Казанский государственный медицинский университет
Казань, Россия

2 Казанский федеральный университет
Казань, Россия

* E-mail: khajrulli@yandex.ru

Поступила в редакцию 06.03.2023
После доработки 21.03.2023
Принята к публикации 22.03.2023

Аннотация

Известно, что в спинальных мотонейронах после поражения верхнего уровня спинного мозга происходит деградация нейронов, сопровождающаяся дегенерацией аксонов. В настоящем исследовании функциональная целостность нервно-мышечной передачи оценивалась методом стимуляционной механомиографии. Мы продемонстрировали снижение модулирующей активности АТФ в холинергическом синапсе вследствие травмы спинного мозга (модель контузионной травмы спинного мозга) в сравнении с гиподинамией (модель антиортостатического вывешивания задних конечностей). Продемонстрированная аномальная модуляция пуринами нервно-мышечного перехода предоставляет доказательства дегенерации аксонов и предполагает, что транссинаптическая дегенерация двигательных нейронов может происходить ниже уровня поражения спинного мозга у пациентов с подобными травмами.

Ключевые слова: денервация, АТФ, Р2-рецепторы, скелетные мышцы, гипогравитационный двигательный синдром, травматический двигательный синдром, синапс, сурамин

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