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Российский физиологический журнал им. И.М. Сеченова, 2023, T. 109, № 8, стр. 1005-1027

Механосенсорные структуры в системе механотрансдукции мышечного волокна

Т. М. Мирзоев 1, *, Б. С. Шенкман 1

1 Институт медико-биологических проблем РАН
Москва, Россия

* E-mail: tmirzoev@yandex.ru

Поступила в редакцию 12.05.2023
После доработки 27.06.2023
Принята к публикации 01.07.2023

Аннотация

Способность скелетных мышц воспринимать механические стимулы и реагировать на них путем изменения внутриклеточных электрохимических и биохимических процессов (механотрансдукция) имеет важнейшее значение для регуляции физиологических процессов в мышечных волокнах. В настоящем обзоре представлена характеристика основных сарколеммальных, саркомерных и цитоскелетных механочувствительных структур, а также проанализированы механо-зависимые сигнальные пути и механизмы, участвующие в регуляции экспрессии генов, а также процессах синтеза и распада белка. В заключительной части обзора сформулированы специфические вопросы в области механотрансдукции скелетных мышц, требующие разрешения в дальнейших исследованиях. Понимание особенностей механотрансдукции в скелетных мышцах необходимо для разработки эффективных средств, направленных на лечение мышечных дистрофий, саркопении, а также профилактики мышечной атрофии, вызванной гипокинезией.

Ключевые слова: скелетная мышца, механосенсоры, механотрансдукция, механический сигнал, функциональная разгрузка, синтез белка, внутриклеточная сигнализация

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