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  4. T. 65, № 3, 2023

Цитология, 2023, T. 65, № 3, стр. 232-245

Убиквитин-протеасомная система в регуляции клеточной плюрипотентности и дифференцировки

У. И. Поденкова 1, И. В. Зубарев 1, А. Н. Томилин 1, А. С. Цимоха 1, *

1 Институт цитологии РАН
194064 Санкт-Петербург, Россия

* E-mail: atsimokha@incras.ru

Поступила в редакцию 30.11.2022
После доработки 05.12.2022
Принята к публикации 05.12.2022

Аннотация

Эмбриональные стволовые клетки (ЭСК) и индуцированные плюрипотентные стволовые клетки (иПСК) демонстрируют уникальную способность к непрерывному самообновлению и дифференцировке во все типы соматических клеток. Понимание механизмов, контролирующих эти свойства, приблизит к эффективному и безопасному использованию ЭСК и иПСК в клеточной терапии. Недавние совокупные данные подчеркнули важность протеостаза в поддержании функции ЭСК. Настоящий обзор посвящен роли убиквитин-протеасомной системы (УПС) – ключевого участника сети протеостаза – в регуляции плюрипотентности и дифференцировки ЭСК и иПСК.

Ключевые слова: деубиквитиназы, дифференцировка, плюрипотентность, протеасома, убиквитин-лигазы, убиквитин-протеасомная система, эмбриональные стволовые клетки

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