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  4. T. 109, № 11, 2023

Российский физиологический журнал им. И.М. Сеченова, 2023, T. 109, № 11, стр. 1617-1634

Экспериментальные модели митохондриальных дисфункций при патогенезе болезней ЦНС на зебраданио

Л. В. Юшко 1, М. М. Котова 1, Т. В. Вьюнова 2, А. В. Калуев 1, 3, 4, 5, *

1 Направление “Нейробиология”, Научный центр генетики и наук о жизни, Научно-технологический университет “Сириус”
Федеральная территория Сириус, Россия

2 Лаборатория технологий нейрореабилитации, Центр Life Improvement by Future Technologies “LIFT”
Москва, Россия

3 Уральский федеральный университет
Екатеринбург, Россия

4 Национальный медицинский исследовательский центр им. В.А. Алмазова МЗ РФ
Санкт-Петербург, Россия

5 Институт трансляционной биомедицины, Санкт-Петербургский государственный университет
Санкт-Петербург, Россия

* E-mail: avkalueff@gmail.com

Поступила в редакцию 09.09.2023
После доработки 04.10.2023
Принята к публикации 04.10.2023

Аннотация

Нарушения функций митохондрий в клетках мозга связаны с патогенезом заболеваний различной этиологии, в том числе болезней Альцгеймера, Паркинсона и Гентингтона, бокового амиотрофический склероза, синдрома Ли, аутизма и других. Для изучения митохондриальных дисфункций и создания новых терапевтических средств большое значение имеют исследования на животных. Помимо традиционных моделей на грызунах, пресноводная костная рыба зебраданио (zebrafish, Danio rerio) представляет особый интерес как модельный объект в силу своих биологических характеристик, практичности и возможности получить больший объем экспериментальных данных. В работе обсуждаются генетические и фармакологические модели митохондриальных дисфункций и связанных с ними неврологических расстройств на грызунах и зебраданио. Приведенные данные указывают на зебраданио как эффективную трансляционную модель для изучения патогенеза различных заболеваний мозга, связанных с митохондриальными дисфункциями.

Ключевые слова: митохондрии, митохондриальные дисфункции, болезни ЦНС, модельные организмы, зебраданио

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