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Российский физиологический журнал им. И.М. Сеченова, 2023, T. 109, № 9, стр. 1199-1216

Анализ поведения и плотности нейронов в головном мозге мышей B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J-модели болезни Паркинсона

И. Н. Рожкова 1, С. В. Окотруб 1, Е. Ю. Брусенцев 1, Т. А. Рахманова 1, 2, Д. А. Лебедева 1, 2, В. С. Козенева 1, 2, Н. В. Хоцкин 1, С. Я. Амстиславский 1, *

1 Институт цитологии и генетики Сибирского отделения Российской академии наук
Новосибирск, Россия

2 Новосибирский национальный исследовательский государственный университет
Новосибирск, Россия

* E-mail: amstis@yandex.ru

Поступила в редакцию 05.06.2023
После доработки 13.07.2023
Принята к публикации 21.07.2023

Аннотация

Болезнь Паркинсона (БП) является прогрессирующей возрастной нейродегенеративной патологией центральной нервной системы, при которой происходит избирательная потеря дофаминергических нейронов нигростриарного пути и для которой характерно наличие специфических включений (телец Леви) в дофаминовых нейронах. Для изучения механизмов возникновения данной патологии и для поиска возможных путей ее коррекции созданы генетические модели БП на мышах. Трансгенные мыши линии B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J (далее в тексте B6.Cg-Tg) имеют мутацию A53T в гене альфа-синуклеина человека и представляют собой модель БП. Целью данной работы было исследование локомоторной активности и уровня тревожности, а также плотности нейронов в головном мозге самцов мышей линии B6.Cg-Tg в возрасте шести месяцев. В качестве контроля были использованы мыши C57BL/6J (дикий тип) того же пола и возраста. Полученные результаты показывают, что для мышей B6.Cg-Tg характерна высокая двигательная активность и низкая тревожность. Наряду с этим у них было обнаружено избирательное снижение плотности нейронов в субвентрикулярной зоне, черной субстанции, а также зонах СА1, СА3, СА4 и гранулярном слое зубчатой извилины гиппокампа. Таким образом, мыши линии B6.Cg-Tg в возрасте шести месяцев лишь частично соответствуют основным патофизиологическим признакам БП, таким как снижение плотности нейронов в черной субстанции, а также в СА1 и СА3 зонах гиппокампа. Однако при этом у них отсутствует брадикинезия и тревожность.

Ключевые слова: мыши C57BL/6J, B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J, болезнь Паркинсона, двигательная активность, тревожность, головной мозг, плотность нейронов

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