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Успехи физиологических наук, 2023, T. 54, № 2, стр. 37-55

Кальциопатии и нейропсихические расстройства: физиологические и генетические аспекты

Н. А. Дюжикова a, М. Б. Павлова a, *

a ФГБУН Институт физиологии им. И.П. Павлова РАН
199034 Санкт-Петербург, Россия

* E-mail: pavlova@infran.ru

Поступила в редакцию 15.06.2022
После доработки 20.11.2022
Принята к публикации 28.12.2022

Аннотация

Кальций является ключевым и универсальным вторичным посредником, эффективным регулятором метаболических процессов. Кальциопатии – нарушения использования кальция в клетке, вызванные дисфункцией субъединиц ионного канала и/или регулирующих их белков, включают отклонения в работе регуляторных путей и митохондрий, сопровождают нейропсихиатрические заболевания. Выявление ассоциированных генов кальциевого обмена и изучение роли изменений в их работе в детерминации подобных состояний важно для поиска новых молекулярных мишеней направленной фармакотерапии расстройств психики и сопутствующих заболеваний, их профилактики. Обзор посвящен рассмотрению физиологических и генетических нарушений в регуляции кальциевого гомеостаза, взаимосвязи с психоневропатологией различного генеза, известным и перспективным терапевтическим подходам к их лечению, основанным на воздействии на процессы кальциевого обмена и активность генов кальциевого ответа.

Ключевые слова: кальций, кальциопатии, психоневрологические расстройства, физиологическая и генетическая детерминация, экспрессия генов, фармакология

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